| 27675 | Tabo | uli | | | Reesink (1976) | |
| 181536 | Sumau | oma | | | Z'graggen (1980) | new |
| 52491 | Suena | seka | new | | Smallhorn (2011) | |
| 30856 | Sowanda | nemik | | | Voorhoeve (1971) | |
| 155582 | Southern Kiwai | orio | | | McElhanon and Voorhoeve (1970) | new |
| 17391 | Southern Kiwai | orio | | | Wurm (1973) | |
| 155584 | Southern Kiwai (Tureture Dialect) | orio | | | McElhanon and Voorhoeve (1970) | new |
| 2447 | Southern Kiwai (Tureture Dialect) | orio | | | Wurm (1973) | |
| 181535 | Sop | oma | | | Z'graggen (1980) | new |
| 15841 | Sonia | hi | | | Shaw (1986) | |
| 91122 | Somba-Siawari (Mindik Dialect) | dâlâkŋi | new | | McElhanon (1967) | new |
| 155635 | Somba-Siawari (Mindik Dialect) | dʌlʌkŋi | | | McElhanon and Voorhoeve (1970) | new |
| 155634 | Somba-Siawari (Burum Dialect) | gbʌlʌ | | | McElhanon and Voorhoeve (1970) | new |
| 91127 | Somba-Siawari (Burum Dialect) | dâlâkŋi | new | | McElhanon (1967) | new |
| 155605 | Som | kwarak | | | McElhanon and Voorhoeve (1970) | new |
| 213874 | Som | kwarak | | | SIL (1968) | |
| 30689 | Skou | nàtɔ | | | Voorhoeve (1971) | |
| 82989 | Sirva | kikɨ | | | Daniels (2010) | |
| 181530 | Siroi | kitek | | | Z'graggen (1980) | new |
| 181522 | Sinsauru | omok | | | Z'graggen (1980) | new |
| 181523 | Sinsauru | fwainim | | | Z'graggen (1980) | new |
| 259111 | Sinaugoro | variɣu- | | | Dutton (1970) | new (house) |
| 4919 | Simbari | aaya | | | Lloyd (1973) | |
| 125668 | Silopi | eroug | | | Z'graggen (1980) | new |
| 125669 | Silopi | zɔr | | | Z'graggen (1980) | new |
| 26907 | Silimo | un | | | Bromley (1967) | |
| 193780 | Sileibi | kʉndəwᵘ | | | Z'graggen (1980) | new |
| 220515 | Sikaritai | sgad̚ | | | Clouse (1997) | |
| 220362 | Sikaritai | sgad̚ | | | Clouse (1997) | |
| 125646 | Sihan | erʌʔ | | | Z'graggen (1980) | new |
| 199508 | Siawi | tʋtʋʔ | | | Conrad and Dye (1975) | |
| 73551 | Siane | kófawá | | | Scott (1978) | |
| 32193 | Siane | gohava | | | SIL (1987) | |
| 155629 | Sialum | gbali | | | McElhanon and Voorhoeve (1970) | new |
| 202669 | Setaman (Seltamin Dialect) | kʰikis | | | Van Cott and Spencer (2010) | |
| 202928 | Setaman (Baktamin Dialect) | kikʰis | | | Van Cott and Spencer (2010) | |
| 155646 | Sene | gbereʔ | | | McElhanon and Voorhoeve (1970) | new |
| 155559 | Sempan | ay | | | McElhanon and Voorhoeve (1970) | new |
| 91119 | Selepet | âiŋe | new | | McElhanon (1967) | new |
| 155639 | Selepet | irak | | | McElhanon and Voorhoeve (1970) | new |
| 30049 | Sawi | xare | | | Voorhoeve (1971) | |
| 75635 | Savosavo | iɰe | | | Wegener (2011) | |
| 181525 | Sausi | amogo | | | Z'graggen (1980) | new |
| 125660 | Saruga | zoi | | | Z'graggen (1980) | new |
| 125659 | Saruga | azegu | | | Z'graggen (1980) | new |
| 220499 | Saponi | aɛjɛ | | | Clouse (1997) | |
| 220346 | Saponi | aɛjɛ | | | Clouse (1997) | |
| 1342 | Saniyo-Hiyewe | hɛʔiyaʔi | | | Macdonald (1973) | |
| 125656 | Samosa | vuga | | | Z'graggen (1980) | new |
| 125657 | Samosa | vugakaugu | | | Z'graggen (1980) | new |
